Synchrotron Services

The Industrial Macromolecular Crystallography Association Collaborative Access Team (IMCA-CAT) accelerates drug discovery through synchrotron-based structural biology research serving the pharmaceutical industry.

Located at the Advanced Photon Source at Argonne National Laboratory, IMCA-CAT is a vital resource that integrates seamlessly into company workflows.

State-of-the-art equipment and ready access are crucial to enabling IMCA-CAT to deliver high-quality structural data at the speed and frequency needed by industry.

IMCA-CAT’s broad experiment envelope of capabilities for both protein crystallography and complementary techniques ensures the successful measurement of X-ray diffraction data from a wide variety of samples.

Opportunities are available for industry to conduct proprietary research at IMCA-CAT, including membership in IMCA (joining AbbVie, Bristol Myers Squibb, Evotec, Janssen, Merck, Novartis, Pfizer, and Relay Therapeutics) and subscription.

The IMCA-CAT team ensures that the research facility performs to the highest standards for quality, reliability, efficiency, and productivity while providing outstanding service for data acquisition, comprehensive security for confidentiality and protection of proprietary information, and expert support for challenging experiments.

Supporting drug discovery projects with >30,000 structures per year.


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  • Intense focused beam
  • Robotics and automation for delivering fully processed data.
  • DECTRIS Eiger2 X 9M detector for high-throughput data collection
  • Diffraction rastering for high-speed precision sample centering


  • High-throughput fragment screening
  • MAD/SAD de novo structure determination
  • Membrane proteins
  • Small crystals
  • Radiation-sensitive samples